Irisin: A Possibly New Therapeutic Target for Obesity and Diabetes Mellitus

Irisin, a newly discovered myokine that reduces obesity and improve insulin resistance via the browning of white adipose tissues. Irisin is expressed and secreted in response to exercise, providing a hormonal link between exercise and improved insulin sensitivity. Several studies reported low irisin level in diabetic patient as compared to control. Therefore,it has been assumed that irisin may be used as an injectable remedy for diseases, relating to metabolism and various other health disorders in which physical exercise leads to improvements, for example, obesity and type II DM. This review focuses on the therapeutic possibility of irisin in patients with obesity and type II DM.